Immune enhancement of nitroreductase-induced cytotoxicity: Studies using a bicistronic adenovirus vector

نویسندگان
چکیده

برای دانلود باید عضویت طلایی داشته باشید

برای دانلود متن کامل این مقاله و بیش از 32 میلیون مقاله دیگر ابتدا ثبت نام کنید

اگر عضو سایت هستید لطفا وارد حساب کاربری خود شوید

منابع مشابه

Enhancement of hyperthermia-induced cytotoxicity by polyamines.

tion, in part due to its ability to inhibit cellular recovery mech anisms (1, 10, 24, 25); (b) heat may increase cellular uptake of certain chemotherapeutic drugs, thus making them more effective (20); and (C) hyperthermia may preferentially kill neoplastic and transformed cells (5, 17, 23). For an extensive review of these rationales, see Ref. 33. In spite of these wide-ranging investigations,...

متن کامل

Adenoviral expression of suppressor of cytokine signaling-1 reduces adenovirus vector-induced innate immune responses.

Adenovirus (Ad) vectors are among the most commonly used viral vectors in gene therapy clinical trials. However, the application of Ad vectors has been limited to local injection in many cases, because the systemic administration of Ad vectors triggers innate immune responses such as inflammatory cytokine production and tissue damage. To overcome this limitation, it will be necessary to develop...

متن کامل

Effect of Clarithromycin on Enhancement of Doxorubicin-induced Cytotoxicity and Apoptosis in A549 Tumor-Cell Line

Background and purpose: Nowadays, multi-drug regimens or combination therapy are new approaches in cancer treatment that combine two or several therapeutic agents. Combination therapy aims at improving the therapeutic efficacy of anticancer drugs while reducing toxicity and preventing drug resistance. The aim of this study was to determine the synergistic effect of combined clarithromycin and d...

متن کامل

Adenovirus vector-induced immune responses in nonhuman primates: responses to prime boost regimens.

In the phase IIb STEP trial an HIV-1 vaccine based on adenovirus (Ad) vectors of the human serotype 5 (AdHu5) not only failed to induce protection but also increased susceptibility to HIV-1 infection in individuals with preexisting neutralizing Abs against AdHu5. The mechanisms underlying the increased HIV-1 acquisition rates have not yet been elucidated. Furthermore, it remains unclear if the ...

متن کامل

TRIF, and TRIF-interacting TLRs differentially modulate several adenovirus vector-induced immune responses.

The use of Adenovirus (Ad)-based vectors has proven to be a useful platform for the development of gene therapy and vaccine protocols. The immunological mechanisms underlying these properties need to be identified and understood to foster safer, more efficacious use of this important gene transfer platform. Our recent studies have confirmed an important role for MyD88 dependent toll-like recept...

متن کامل

ذخیره در منابع من


  با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید

ژورنال

عنوان ژورنال: International Journal of Cancer

سال: 2003

ISSN: 0020-7136,1097-0215

DOI: 10.1002/ijc.10916